Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth. [electronic resource]
Producer: 20141028Description: 1190-203 p. digitalISSN:- 1557-3265
- Animals
- Antineoplastic Agents -- pharmacology
- Camptothecin -- analogs & derivatives
- Cell Line, Tumor
- DNA Breaks, Double-Stranded -- drug effects
- DNA Damage -- drug effects
- Dioxoles -- pharmacology
- Disease Models, Animal
- Doxorubicin -- pharmacology
- Drug Resistance, Neoplasm -- genetics
- Drug Synergism
- Exodeoxyribonucleases -- genetics
- Female
- Gene Expression Regulation, Neoplastic -- drug effects
- Gene Silencing
- Humans
- Irinotecan
- Mice
- Oncogene Proteins, Fusion -- antagonists & inhibitors
- Phenotype
- Proto-Oncogene Protein c-fli-1 -- antagonists & inhibitors
- RNA Interference
- RNA, Small Interfering -- genetics
- RNA-Binding Protein EWS -- antagonists & inhibitors
- RecQ Helicases -- genetics
- Sarcoma, Ewing -- drug therapy
- Tetrahydroisoquinolines -- pharmacology
- Trabectedin
- Werner Syndrome Helicase
- Xenograft Model Antitumor Assays
No physical items for this record
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
There are no comments on this title.
Log in to your account to post a comment.