Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1. [electronic resource]
Producer: 20070306Description: 1211-9 p. digitalISSN:- 0006-4971
- Active Transport, Cell Nucleus
- Apoptosis
- Basic-Leucine Zipper Transcription Factors -- metabolism
- Cell Line
- Fusion Proteins, bcr-abl -- physiology
- Heme Oxygenase-1 -- antagonists & inhibitors
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphorylation
- Protein Processing, Post-Translational -- physiology
- Repressor Proteins
- Ribosomal Protein S6 Kinases -- metabolism
- Signal Transduction
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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