Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues. [electronic resource]
Producer: 20030730Description: 2941-52 p. digitalISSN:- 0968-0896
- Animals
- Antineoplastic Agents, Alkylating -- chemical synthesis
- Binding Sites
- Bone Marrow Cells -- drug effects
- Cell Cycle -- drug effects
- Cell Division -- drug effects
- DNA -- metabolism
- DNA Adducts -- chemical synthesis
- Drug Design
- Drug Screening Assays, Antitumor
- Duocarmycins
- Furans -- chemistry
- Hematopoietic Stem Cells -- drug effects
- Indoles
- Mice
- Models, Molecular
- Pyrroles -- chemistry
- Quinolines
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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