Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death. [electronic resource]
Producer: 20130531Description: e444 p. digitalISSN:- 2041-4889
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Cell Death
- Cell Membrane Permeability -- drug effects
- Glycogen Synthase Kinase 3 -- genetics
- Glycogen Synthase Kinase 3 beta
- Humans
- Mice
- Mice, Inbred BALB C
- Mitochondria -- drug effects
- Neoplasms -- enzymology
- Oxidative Stress -- drug effects
- Protein Binding -- drug effects
- bcl-2-Associated X Protein -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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