Discovery and SAR of potent, orally available and brain-penetrable 5,6-dihydro-4H-3-thia-1-aza-benzo[e]azulen- and 4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen derivatives as neuropeptide Y Y5 receptor antagonists. [electronic resource]
Producer: 20041222Description: 2451-7 p. digitalISSN:- 0960-894X
- Administration, Oral
- Animals
- Azulenes
- Biological Availability
- Blood
- Blood-Brain Barrier
- Cycloheptanes -- chemical synthesis
- Heterocyclic Compounds, 3-Ring -- chemical synthesis
- Heterocyclic Compounds, 4 or More Rings -- chemical synthesis
- Hypothalamus
- Inhibitory Concentration 50
- Rats
- Receptors, Neuropeptide Y -- antagonists & inhibitors
- Structure-Activity Relationship
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Publication Type: Journal Article
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