Interleukin-1β promotes ovarian tumorigenesis through a p53/NF-κB-mediated inflammatory response in stromal fibroblasts. [electronic resource]
Producer: 20130918Description: 409-20 p. digitalISSN:- 1476-5586
- Adult
- Aged
- Aged, 80 and over
- Animals
- Apoptosis
- Carcinoma -- immunology
- Cell Line, Tumor
- Cell Proliferation
- Cell Transformation, Neoplastic -- immunology
- Chemokines -- metabolism
- Female
- Fibroblasts -- immunology
- Gene Expression Regulation, Neoplastic
- Gene Silencing
- Humans
- Interleukin-1beta -- physiology
- Kaplan-Meier Estimate
- Mice
- Mice, Nude
- Middle Aged
- Neoplasm Transplantation
- Ovarian Neoplasms -- immunology
- Paracrine Communication
- Receptors, Interleukin-1 -- metabolism
- Signal Transduction -- immunology
- Stromal Cells -- immunology
- Tissue Array Analysis
- Transcription Factor RelA -- metabolism
- Transcriptional Activation
- Tumor Burden
- Tumor Suppressor Protein p53 -- genetics
- Young Adult
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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