Synthesis of phenstatin/isocombretastatin-chalcone conjugates as potent tubulin polymerization inhibitors and mitochondrial apoptotic inducers. [electronic resource]
Producer: 20151208Description: 3963-81 p. digitalISSN:- 1477-0539
- Apoptosis -- drug effects
- Binding, Competitive
- Caspase 9 -- metabolism
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Chalcone -- chemical synthesis
- Chemistry Techniques, Synthetic
- Chlorophenols -- chemistry
- DNA Fragmentation -- drug effects
- Drug Screening Assays, Antitumor
- Enzyme Activation -- drug effects
- Humans
- Membrane Potential, Mitochondrial -- drug effects
- Mitochondria -- drug effects
- Models, Molecular
- Peptides, Cyclic -- chemistry
- Protein Multimerization -- drug effects
- Protein Structure, Secondary
- Tubulin -- chemistry
- Tubulin Modulators -- chemical synthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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