Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age. [electronic resource]
Producer: 20130117Description: 3229-36 p. digitalISSN:- 1528-0020
- Adaptor Proteins, Signal Transducing -- genetics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Aging -- genetics
- Blotting, Western
- Child
- Child, Preschool
- Colony-Forming Units Assay
- Female
- Flow Cytometry
- Hematopoietic Stem Cells -- metabolism
- Humans
- Immunoenzyme Techniques
- Infant
- Infant, Newborn
- Male
- Microsatellite Instability
- Middle Aged
- MutL Protein Homolog 1
- MutS Homolog 2 Protein -- genetics
- Nuclear Proteins -- genetics
- Prognosis
- RNA, Messenger -- genetics
- Real-Time Polymerase Chain Reaction
- Reverse Transcriptase Polymerase Chain Reaction
- Stem Cells -- metabolism
- Young Adult
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
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