Reduced dNTP binding affinity of 3TC-resistant M184I HIV-1 reverse transcriptase variants responsible for viral infection failure in macrophage. [electronic resource]
Producer: 20080522Description: 9206-16 p. digitalISSN:- 0021-9258
- Amino Acid Substitution
- Cell Line
- DNA, Viral -- biosynthesis
- Deoxyribonucleotides -- metabolism
- Drug Resistance, Viral -- genetics
- HIV Infections -- enzymology
- HIV Reverse Transcriptase -- genetics
- HIV-1 -- enzymology
- Humans
- Lamivudine -- pharmacology
- Macrophages -- metabolism
- Mutation, Missense
- Protein Structure, Quaternary -- genetics
- Protein Structure, Secondary -- genetics
- Reverse Transcriptase Inhibitors -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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