Relapse of acute promyelocytic leukemia with PML-RARalpha mutant subclones independent of proximate all-trans retinoic acid selection pressure. [electronic resource]
Producer: 20060908Description: 556-62 p. digitalISSN:- 0887-6924
- Adult
- Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
- Binding Sites
- Cell Lineage
- Clone Cells
- Drug Resistance, Neoplasm -- genetics
- Epigenesis, Genetic
- Humans
- Leukemia, Promyelocytic, Acute -- drug therapy
- Mutation
- Neoplasm Proteins -- drug effects
- Oncogene Proteins, Fusion -- drug effects
- Recurrence
- Remission Induction
- Reverse Transcriptase Polymerase Chain Reaction
- Sensitivity and Specificity
- Structure-Activity Relationship
- Tretinoin -- adverse effects
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Publication Type: Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
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