Tat expression led to increased histone 3 tri-methylation at lysine 27 and contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression. [electronic resource]
Producer: 20200930Description: 508-519 p. digitalISSN:- 1538-2443
- Astrocytes -- drug effects
- Cell Line, Tumor
- Enhancer of Zeste Homolog 2 Protein -- antagonists & inhibitors
- Fibroblasts -- drug effects
- Gene Expression Regulation
- Genes, Reporter
- Green Fluorescent Proteins -- genetics
- HEK293 Cells
- HIV-1 -- drug effects
- Histones -- genetics
- Host-Pathogen Interactions -- drug effects
- Humans
- Indoles -- pharmacology
- Jurkat Cells
- Luminescent Proteins -- genetics
- Methyl-CpG-Binding Protein 2 -- genetics
- Methylation
- Pyridones -- pharmacology
- Signal Transduction
- Vesiculovirus -- genetics
- Virus Latency -- drug effects
- tat Gene Products, Human Immunodeficiency Virus -- genetics
- Red Fluorescent Protein
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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