Renal tumours in a Tsc2(+/-) mouse model do not show feedback inhibition of Akt and are effectively prevented by rapamycin. [electronic resource]
Producer: 20150410Description: 922-31 p. digitalISSN:- 1476-5594
- Animals
- Antibiotics, Antineoplastic -- pharmacology
- Gene Expression Regulation, Neoplastic -- drug effects
- Kidney Neoplasms -- genetics
- Mechanistic Target of Rapamycin Complex 1
- Mechanistic Target of Rapamycin Complex 2
- Mice
- Mice, Mutant Strains
- Multiprotein Complexes -- genetics
- Neoplasms, Experimental -- genetics
- Phosphorylation -- drug effects
- Proto-Oncogene Proteins c-akt -- genetics
- Signal Transduction -- drug effects
- Sirolimus -- pharmacology
- TOR Serine-Threonine Kinases -- genetics
- Tuberous Sclerosis Complex 2 Protein
- Tumor Suppressor Proteins -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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