Specific targeting of insulin-like growth factor 1 receptor signaling in human estrogen dependent breast cancer cell by a novel tyrosine-based benzoxazepine derivative. [electronic resource]
Producer: 20111031Description: 68-78 p. digitalISSN:- 1872-8057
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Binding Sites
- Breast Neoplasms -- metabolism
- Caspase 8 -- metabolism
- Cell Line, Tumor
- Drug Screening Assays, Antitumor
- Enzyme Activation
- Estrogens -- metabolism
- Female
- Humans
- Insulin -- pharmacology
- Insulin-Like Growth Factor I -- pharmacology
- Membrane Potential, Mitochondrial -- drug effects
- Mice
- Mice, Nude
- Models, Molecular
- Neoplasm Transplantation
- Oxazepines -- pharmacology
- Phosphorylation
- Receptor, IGF Type 1 -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Sulfonamides -- pharmacology
- Transplantation, Heterologous
- Tyrosine -- analogs & derivatives
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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