Obatoclax, a BH3 Mimetic, Enhances Cisplatin-Induced Apoptosis and Decreases the Clonogenicity of Muscle Invasive Bladder Cancer Cells via Mechanisms That Involve the Inhibition of Pro-Survival Molecules as Well as Cell Cycle Regulators. [electronic resource]
Producer: 20190716ISSN:- 1422-0067
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Cisplatin -- pharmacology
- Cyclin D1 -- metabolism
- Cyclin-Dependent Kinase 4 -- metabolism
- Cyclin-Dependent Kinase 6 -- metabolism
- Dose-Response Relationship, Drug
- Drug Synergism
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Indoles
- Neoplasm Invasiveness
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Pyrroles -- pharmacology
- Urinary Bladder -- drug effects
- Urinary Bladder Neoplasms -- drug therapy
- bcl-X Protein -- metabolism
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Publication Type: Journal Article
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