Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures. [electronic resource]
Producer: 20170811Description: 4840-4860 p. digitalISSN:- 1520-4804
- Animals
- Antimalarials -- chemistry
- Arabidopsis Proteins -- antagonists & inhibitors
- Chemistry Techniques, Synthetic
- Crystallography, X-Ray
- Cysteine -- chemistry
- Drug Stability
- Enzyme Inhibitors -- chemistry
- Glycine Hydroxymethyltransferase -- antagonists & inhibitors
- Half-Life
- Ligands
- Malaria, Falciparum -- drug therapy
- Mice, SCID
- Plasmodium falciparum -- drug effects
- Plasmodium vivax -- enzymology
- Protein Conformation
- Rats
- Structure-Activity Relationship
- Thiophenes -- chemical synthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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