Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo. [electronic resource]
Producer: 20100709Description: 537-49 p. digitalISSN:- 1365-2141
- Animals
- Antineoplastic Agents -- pharmacology
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Cell Death -- drug effects
- Dose-Response Relationship, Drug
- Humans
- MAP Kinase Kinase 1 -- antagonists & inhibitors
- MAP Kinase Kinase 2 -- antagonists & inhibitors
- MAP Kinase Signaling System -- drug effects
- Mice
- Mice, SCID
- Multiple Myeloma -- drug therapy
- Niacinamide -- analogs & derivatives
- Protein Kinase Inhibitors -- pharmacology
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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