iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates. [electronic resource]
Producer: 20200421Description: 289-299 p. digitalISSN:- 1546-170X
- Adult
- Age of Onset
- Animals
- Cell Differentiation -- genetics
- Dopamine -- metabolism
- Dopaminergic Neurons -- metabolism
- Humans
- Induced Pluripotent Stem Cells -- metabolism
- Leukocytes, Mononuclear -- cytology
- Lysosomes -- metabolism
- Membrane Proteins -- metabolism
- Mice
- Mice, Inbred C57BL
- Mutation
- Parkinson Disease -- genetics
- Patch-Clamp Techniques
- Phenotype
- Phorbol Esters
- Phosphorylation
- Proteomics
- Transcriptome
- alpha-Synuclein -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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