Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines. [electronic resource]
Producer: 20110916Description: 372-81 p. digitalISSN:- 1532-1827
- Animals
- Antineoplastic Agents -- therapeutic use
- Ataxia Telangiectasia Mutated Proteins
- Breast Neoplasms -- drug therapy
- Cell Cycle -- drug effects
- Cell Cycle Proteins -- antagonists & inhibitors
- Cell Line, Tumor
- DNA Damage -- drug effects
- DNA Mismatch Repair -- drug effects
- Drug Evaluation, Preclinical
- Female
- Genes, p53
- Humans
- Leukemia L1210
- Mice
- Nitroso Compounds -- therapeutic use
- Ovarian Neoplasms -- drug therapy
- Poly (ADP-Ribose) Polymerase-1
- Poly(ADP-ribose) Polymerases -- metabolism
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Pyrimidines -- therapeutic use
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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