Thy-1 signaling in the context of costimulation provided by dendritic cells provides signal 1 for T cell proliferation and cytotoxic effector molecule expression, but fails to trigger delivery of the lethal hit. [electronic resource]
Producer: 20030922Description: 69-77 p. digitalISSN:- 0022-1767
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal -- pharmacology
- CD28 Antigens -- physiology
- Cytotoxicity Tests, Immunologic -- methods
- Cytotoxicity, Immunologic -- genetics
- Dendritic Cells -- immunology
- Interleukin-2 -- biosynthesis
- Lymphocyte Activation -- genetics
- Mice
- Mice, Inbred BALB C
- Mice, Knockout
- Mice, Transgenic
- Molecular Sequence Data
- Receptor-CD3 Complex, Antigen, T-Cell -- genetics
- Receptors, IgG -- deficiency
- Signal Transduction -- genetics
- T-Lymphocytes, Cytotoxic -- immunology
- Thy-1 Antigens -- immunology
- Tumor Cells, Cultured
- Up-Regulation -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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