The Nef-mediated AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with increased Fas/FasL expression on T cells and T-cell death but is not prevented in Fas-, FasL-, tumor necrosis factor receptor 1-, or interleukin-1beta-converting enzyme-deficient or Bcl2-expressing transgenic mice. [electronic resource]
Producer: 20050620Description: 6377-91 p. digitalISSN:- 0022-538X
- Acquired Immunodeficiency Syndrome -- genetics
- Animals
- Apoptosis
- Caspase 1 -- deficiency
- Disease Models, Animal
- Edema -- pathology
- Fas Ligand Protein
- Genes, nef -- physiology
- HIV-1 -- genetics
- Kidney -- pathology
- Lymph Nodes -- pathology
- Membrane Glycoproteins -- deficiency
- Mice
- Mice, Transgenic
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-bcl-2
- T-Lymphocytes -- immunology
- TNF Receptor-Associated Factor 1 -- deficiency
- Thymus Gland -- pathology
- Weight Loss
- fas Receptor -- genetics
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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