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Discovery and SAR of potent, orally available and brain-penetrable 5,6-dihydro-4H-3-thia-1-aza-benzo[e]azulen- and 4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen derivatives as neuropeptide Y Y5 receptor antagonists. [electronic resource] by
- Rueeger, Heinrich
- Gerspacher, Marc
- Buehlmayer, Peter
- Rigollier, Pascal
- Yamaguchi, Yasuchika
- Schmidlin, Tibur
- Whitebread, Steven
- Nuesslein-Hildesheim, Barbara
- Nick, Hanspeter
- Cricione, Leoluca
Producer: 20041222
In:
Bioorganic & medicinal chemistry letters vol. 14
Availability: No items available.
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Structural modification of the P2' position of 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets. [electronic resource] by
- Maibaum, Jürgen
- Stutz, Stefan
- Göschke, Richard
- Rigollier, Pascal
- Yamaguchi, Yasuchika
- Cumin, Frédéric
- Rahuel, Joseph
- Baum, Hans-Peter
- Cohen, Nissim-Claude
- Schnell, Christian R
- Fuhrer, Walter
- Gruetter, Markus G
- Schilling, Walter
- Wood, Jeanette M
Producer: 20071121
In:
Journal of medicinal chemistry vol. 50
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Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo. [electronic resource] by
- Velcicky, Juraj
- Bodendorf, Ursula
- Rigollier, Pascal
- Epple, Robert
- Beisner, Daniel R
- Guerini, Danilo
- Smith, Philip
- Liu, Bo
- Feifel, Roland
- Wipfli, Peter
- Aichholz, Reiner
- Couttet, Philippe
- Dix, Ina
- Widmer, Toni
- Wen, Ben
- Brandl, Trixi
Producer: 20190225
In:
Journal of medicinal chemistry vol. 61
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Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors. [electronic resource] by
- Velcicky, Juraj
- Mathison, Casey J N
- Nikulin, Victor
- Pflieger, Daniel
- Epple, Robert
- Azimioara, Mihai
- Cow, Christopher
- Michellys, Pierre-Yves
- Rigollier, Pascal
- Beisner, Daniel R
- Bodendorf, Ursula
- Guerini, Danilo
- Liu, Bo
- Wen, Ben
- Zaharevitz, Samantha
- Brandl, Trixi
Publication details: ACS medicinal chemistry letters Jun 2019
In:
ACS medicinal chemistry letters vol. 10
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Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin. [electronic resource] by
- Göschke, Richard
- Stutz, Stefan
- Rasetti, Vittorio
- Cohen, Nissim-Claude
- Rahuel, Joseph
- Rigollier, Pascal
- Baum, Hans-Peter
- Forgiarini, Peter
- Schnell, Christian R
- Wagner, Trixie
- Gruetter, Markus G
- Fuhrer, Walter
- Schilling, Walter
- Cumin, Frédéric
- Wood, Jeanette M
- Maibaum, Jürgen
Producer: 20071121
In:
Journal of medicinal chemistry vol. 50
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Key aspects of the Novartis compound collection enhancement project for the compilation of a comprehensive chemogenomics drug discovery screening collection. [electronic resource] by
- Jacoby, Edgar
- Schuffenhauer, Ansgar
- Popov, Maxim
- Azzaoui, Kamal
- Havill, Benjamin
- Schopfer, Ulrich
- Engeloch, Caroline
- Stanek, Jaroslav
- Acklin, Pierre
- Rigollier, Pascal
- Stoll, Friederike
- Koch, Guido
- Meier, Peter
- Orain, David
- Giger, Rudolph
- Hinrichs, Jürgen
- Malagu, Karine
- Zimmermann, Jürg
- Roth, Hans-Joerg
Producer: 20050627
In:
Current topics in medicinal chemistry vol. 5
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Structure-based design of aliskiren, a novel orally effective renin inhibitor. [electronic resource] by
- Wood, Jeanette M
- Maibaum, Jürgen
- Rahuel, Joseph
- Grütter, Markus G
- Cohen, Nissim-Claude
- Rasetti, Vittorio
- Rüger, Heinrich
- Göschke, Richard
- Stutz, Stefan
- Fuhrer, Walter
- Schilling, Walter
- Rigollier, Pascal
- Yamaguchi, Yasuchika
- Cumin, Frederic
- Baum, Hans-Peter
- Schnell, Christian R
- Herold, Peter
- Mah, Robert
- Jensen, Chris
- O'Brien, Eoin
- Stanton, Alice
- Bedigian, Martin P
Producer: 20031014
In:
Biochemical and biophysical research communications vol. 308
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Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39. [electronic resource] by
- Bassilana, Frederic
- Carlson, Adam
- DaSilva, Jennifer A
- Grosshans, Bianka
- Vidal, Solange
- Beck, Valerie
- Wilmeringwetter, Barbara
- Llamas, Luis A
- Showalter, Todd B
- Rigollier, Pascal
- Bourret, Aaron
- Ramamurthy, Arun
- Wu, Xu
- Harbinski, Fred
- Plonsky, Samantha
- Lee, Lac
- Ruffner, Heinz
- Grandi, Paola
- Schirle, Markus
- Jenkins, Jeremy
- Sailer, Andreas W
- Bouwmeester, Tewis
- Porter, Jeffrey A
- Myer, Vic
- Finan, Peter M
- Tallarico, John A
- Kelleher, Joseph F
- Seuwen, Klaus
- Jain, Rishi K
- Luchansky, Sarah J
Producer: 20140609
In:
Nature chemical biology vol. 10
Availability: No items available.
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