Polyethylene glycol conjugates of methotrexate varying in their molecular weight from MW 750 to MW 40000: synthesis, characterization, and structure-activity relationships in vitro and in vivo. [electronic resource]
Producer: 20030805Description: 773-85 p. digitalISSN:- 1043-1802
- Animals
- Antimetabolites, Antineoplastic -- administration & dosage
- Cell Division -- drug effects
- Cross-Linking Reagents -- chemistry
- Dose-Response Relationship, Drug
- Drug Carriers -- chemistry
- Drug Evaluation, Preclinical
- Female
- Humans
- Inhibitory Concentration 50
- Methotrexate -- administration & dosage
- Mice
- Mice, Nude
- Molecular Weight
- Neoplasms, Experimental -- drug therapy
- Polyethylene Glycols -- chemistry
- Structure-Activity Relationship
- Tetrahydrofolate Dehydrogenase -- drug effects
- Transplantation, Heterologous
- Tumor Cells, Cultured
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Publication Type: Journal Article
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