Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. [electronic resource]
Producer: 20030916Description: 3799-810 p. digitalISSN:- 0013-7227
- Animals
- Blood Glucose
- Body Weight -- physiology
- Cattle
- Dwarfism, Pituitary -- blood
- Eating -- physiology
- Female
- Gene Deletion
- Genotype
- Growth Hormone -- antagonists & inhibitors
- Insulin -- blood
- Insulin-Like Growth Factor Binding Proteins -- blood
- Insulin-Like Growth Factor I -- metabolism
- Longevity -- physiology
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- Organ Size -- physiology
- Receptors, Somatotropin -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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