Temozolomide Induces Senescence and Repression of DNA Repair Pathways in Glioblastoma Cells via Activation of ATR-CHK1, p21, and NF-κB. [electronic resource]
Producer: 20191021Description: 99-113 p. digitalISSN:- 1538-7445
- Animals
- Antineoplastic Agents, Alkylating -- pharmacology
- Apoptosis
- Ataxia Telangiectasia Mutated Proteins -- genetics
- Cell Cycle
- Cell Proliferation
- Cellular Senescence
- Checkpoint Kinase 1 -- genetics
- Cyclin-Dependent Kinase Inhibitor p21 -- genetics
- DNA Methylation
- DNA Repair -- drug effects
- DNA Repair Enzymes -- antagonists & inhibitors
- Female
- Gene Expression Regulation, Neoplastic
- Glioblastoma -- drug therapy
- Humans
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- NF-kappa B -- genetics
- Temozolomide -- pharmacology
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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