Naphthoquinoxaline metabolite of mitoxantrone is less cardiotoxic than the parent compound and it can be a more cardiosafe drug in anticancer therapy. [electronic resource]
Producer: 20170911Description: 1871-1890 p. digitalISSN:- 1432-0738
- Adenine -- analogs & derivatives
- Adenosine Triphosphate -- metabolism
- Animals
- Antineoplastic Agents -- administration & dosage
- Autophagy -- drug effects
- Cardiotoxicity -- etiology
- Cell Line
- Dose-Response Relationship, Drug
- Lactic Acid -- metabolism
- Membrane Potential, Mitochondrial -- drug effects
- Mitoxantrone -- administration & dosage
- Myocytes, Cardiac -- drug effects
- Quinoxalines -- metabolism
- Rats
- Time Factors
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Publication Type: Comparative Study; Journal Article
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