The MEK inhibitor selumetinib complements CTLA-4 blockade by reprogramming the tumor immune microenvironment. [electronic resource]
Producer: 20180521Description: 63 p. digitalISSN:- 2051-1426
- Animals
- Antibodies, Monoclonal -- administration & dosage
- Antibodies, Monoclonal, Humanized
- Benzimidazoles -- administration & dosage
- Biomarkers, Tumor -- genetics
- Cell Line, Tumor
- Cellular Reprogramming -- drug effects
- Colorectal Neoplasms -- drug therapy
- Drug Synergism
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Mice
- Mutation
- Proto-Oncogene Proteins p21(ras) -- genetics
- Tumor Microenvironment -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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