Myo-inositol trispyrophosphate-mediated hypoxia reversion controls pancreatic cancer in rodents and enhances gemcitabine efficacy. [electronic resource]
Producer: 20140522Description: 2572-82 p. digitalISSN:- 1097-0215
- Animals
- Antimetabolites, Antineoplastic -- therapeutic use
- Apoptosis -- drug effects
- Blotting, Western
- Cell Proliferation -- drug effects
- Deoxycytidine -- analogs & derivatives
- Drug Synergism
- Fluorescent Antibody Technique
- Humans
- Hypoxia -- drug therapy
- Hypoxia-Inducible Factor 1, alpha Subunit -- antagonists & inhibitors
- Inositol Phosphates -- therapeutic use
- Liver Neoplasms -- drug therapy
- Male
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Neovascularization, Pathologic
- Oxygen -- metabolism
- Pancreatic Neoplasms -- drug therapy
- RNA, Messenger -- genetics
- Rats
- Rats, Inbred Lew
- Real-Time Polymerase Chain Reaction
- Reverse Transcriptase Polymerase Chain Reaction
- Tumor Cells, Cultured
- Gemcitabine
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Publication Type: Journal Article
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