A small molecule inhibitor of PCSK9 that antagonizes LDL receptor binding via interaction with a cryptic PCSK9 binding groove. [electronic resource]
Producer: 20210427Description: 115344 p. digitalISSN:- 1464-3391
- Animals
- Binding Sites -- drug effects
- Dose-Response Relationship, Drug
- Enzyme Inhibitors
- Female
- Hep G2 Cells
- Humans
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Molecular Structure
- PCSK9 Inhibitors
- Proprotein Convertase 9 -- deficiency
- Receptors, LDL -- antagonists & inhibitors
- Small Molecule Libraries -- chemical synthesis
- Structure-Activity Relationship
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Publication Type: Journal Article
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