Thermodynamic and biological evaluation of a thrombin binding aptamer modified with several unlocked nucleic acid (UNA) monomers and a 2'-C-piperazino-UNA monomer. [electronic resource]
Producer: 20120208Description: 4739-45 p. digitalISSN:- 1464-3391
- Anticoagulants -- chemical synthesis
- Aptamers, Nucleotide -- chemical synthesis
- Blood Coagulation
- Circular Dichroism
- Drug Design
- Drug Evaluation, Preclinical
- G-Quadruplexes
- Hot Temperature
- Molecular Targeted Therapy
- Nucleic Acid Conformation
- Nucleic Acids -- chemistry
- Oligonucleotides -- analysis
- Piperazines -- chemistry
- Spectrophotometry
- Thermodynamics
- Thrombin -- metabolism
- Thrombin Time
- Uracil -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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