Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension. [electronic resource]
Producer: 20160819Description: 14573 p. digitalISSN:- 2045-2322
- Animals
- Biomarkers
- Cell Line
- Disease Models, Animal
- Hedgehog Proteins -- genetics
- Hemodynamics -- drug effects
- Hepatic Stellate Cells -- drug effects
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- Hypertension, Portal -- drug therapy
- Liver Cirrhosis -- complications
- Models, Biological
- Neovascularization, Pathologic -- drug therapy
- Rats
- Signal Transduction -- drug effects
- rhoA GTP-Binding Protein -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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