A metabolomic and pharmacokinetic study on the mechanism underlying the lipid-lowering effect of orally administered berberine. [electronic resource]
Producer: 20160229Description: 463-74 p. digitalISSN:- 1742-2051
- Administration, Oral
- Animals
- Berberine -- administration & dosage
- Body Weight -- drug effects
- Cholestanetriol 26-Monooxygenase -- genetics
- Cholesterol 7-alpha-Hydroxylase -- genetics
- Cholic Acid -- metabolism
- Chromatography, Gas
- Diet, High-Fat
- Gallbladder -- drug effects
- Gastrointestinal Tract -- drug effects
- Gene Expression Regulation, Enzymologic -- drug effects
- Hep G2 Cells
- Humans
- Hyperlipidemias -- blood
- Hypolipidemic Agents -- administration & dosage
- Lipids -- blood
- Liver -- metabolism
- Male
- Mass Spectrometry
- Mesocricetus
- Metabolomics
- Microbiota -- drug effects
- RNA, Messenger -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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