Studies on the pharmacokinetics and metabolism of a gamma-secretase inhibitor BMS-299897, and exploratory investigation of CYP enzyme induction. [electronic resource]
Producer: 20091001Description: 544-55 p. digitalISSN:- 1366-5928
- ATP Binding Cassette Transporter, Subfamily B, Member 1 -- metabolism
- Adult
- Amyloid Precursor Protein Secretases -- antagonists & inhibitors
- Amyloid beta-Peptides -- metabolism
- Animals
- Antibiotics, Antitubercular -- pharmacokinetics
- Biological Availability
- Brain -- enzymology
- Butyrates -- pharmacokinetics
- Cells, Cultured
- Cytochrome P-450 CYP3A -- biosynthesis
- Cytochrome P-450 Enzyme System -- biosynthesis
- Dogs
- Enzyme Induction -- drug effects
- Female
- Guinea Pigs
- Hepatocytes -- cytology
- Humans
- Hydrocarbons, Halogenated -- pharmacokinetics
- Male
- Mice
- Mice, Knockout
- Pregnane X Receptor
- Rats
- Rats, Sprague-Dawley
- Receptors, Steroid -- metabolism
- Rifampin -- pharmacokinetics
- Species Specificity
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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