Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts. [electronic resource]
Producer: 20201204ISSN:- 1422-0067
- Active Transport, Cell Nucleus
- Adaptor Proteins, Signal Transducing
- Alveolar Epithelial Cells -- metabolism
- Animals
- Bleomycin -- adverse effects
- Cell Cycle Proteins -- metabolism
- Fibroblasts -- metabolism
- Fibronectins -- genetics
- Gene Deletion
- Gene Expression
- Hippo Signaling Pathway
- Humans
- Idiopathic Pulmonary Fibrosis -- etiology
- Immunohistochemistry
- Lysophospholipids -- metabolism
- Methanol -- analogs & derivatives
- Mice
- Mitochondria -- metabolism
- Phosphotransferases (Alcohol Group Acceptor) -- antagonists & inhibitors
- Protein Serine-Threonine Kinases -- metabolism
- Pyrrolidines -- pharmacology
- Reactive Oxygen Species -- metabolism
- Signal Transduction
- Sphingosine -- analogs & derivatives
- Sulfones
- Transcription Factors -- metabolism
- Transforming Growth Factor beta1 -- metabolism
- YAP-Signaling Proteins
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Publication Type: Journal Article
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