Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: toxicokinetics is essential for in vivo-in vitro comparisons. [electronic resource]
Producer: 20130917Description: 505-15 p. digitalISSN:- 1432-0738
- Animals
- Apoptosis -- drug effects
- Benzo(a)pyrene -- pharmacokinetics
- Carcinogenicity Tests -- methods
- Carcinogens -- pharmacokinetics
- Cell Transformation, Neoplastic -- chemically induced
- Cells, Cultured
- Computer Simulation
- DNA Adducts -- metabolism
- DNA Replication -- drug effects
- Dose-Response Relationship, Drug
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic -- drug effects
- Hepatocytes -- drug effects
- High-Throughput Screening Assays
- Liver -- drug effects
- Liver Neoplasms -- chemically induced
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Models, Biological
- Primary Cell Culture
- Risk Assessment
- Transcription, Genetic -- drug effects
- Tumor Suppressor Protein p53 -- genetics
- Xeroderma Pigmentosum Group A Protein -- genetics
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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