Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA. [electronic resource]
Producer: 20090604Description: 2327-35 p. digitalISSN:- 1362-4962
- Animals
- Chromosome Breakage
- Chromosome Fragile Sites
- DNA Polymerase gamma
- DNA Replication
- DNA, Mitochondrial -- biosynthesis
- DNA-Directed DNA Polymerase -- genetics
- Female
- Liver -- metabolism
- Mice
- Mice, Mutant Strains
- Mitochondria -- enzymology
- Progeria -- genetics
- Sequence Analysis, DNA
- Single-Strand Specific DNA and RNA Endonucleases
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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