Results
|
|
1.
|
|
|
|
2.
|
|
|
|
3.
|
Metabolism and disposition of the DOT1L inhibitor, pinometostat (EPZ-5676), in rat, dog and human. [electronic resource] by
- Waters, Nigel J
- Smith, Sherri A
- Olhava, Edward J
- Duncan, Kenneth W
- Burton, Richard D
- O'Neill, James
- Rodrigue, Marie-Eve
- Pollock, Roy M
- Moyer, Mikel P
- Chesworth, Richard
Producer: 20160517
In:
Cancer chemotherapy and pharmacology vol. 77
Availability: No items available.
|
|
|
4.
|
Exploring drug delivery for the DOT1L inhibitor pinometostat (EPZ-5676): Subcutaneous administration as an alternative to continuous IV infusion, in the pursuit of an epigenetic target. [electronic resource] by
- Waters, Nigel J
- Daigle, Scott R
- Rehlaender, Bruce N
- Basavapathruni, Aravind
- Campbell, Carly T
- Jensen, Tyler B
- Truitt, Brett F
- Olhava, Edward J
- Pollock, Roy M
- Stickland, Kim A
- Dovletoglou, Angelos
Producer: 20161005
In:
Journal of controlled release : official journal of the Controlled Release Society vol. 220
Availability: No items available.
|
|
|
5.
|
DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells. [electronic resource] by
- Klaus, Christine R
- Iwanowicz, Dorothy
- Johnston, Danielle
- Campbell, Carly A
- Smith, Jesse J
- Moyer, Mikel P
- Copeland, Robert A
- Olhava, Edward J
- Scott, Margaret Porter
- Pollock, Roy M
- Daigle, Scott R
- Raimondi, Alejandra
Producer: 20140929
In:
The Journal of pharmacology and experimental therapeutics vol. 350
Availability: No items available.
|
|
|
6.
|
MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition. [electronic resource] by
- Kühn, Michael W M
- Hadler, Michael J
- Daigle, Scott R
- Koche, Richard P
- Krivtsov, Andrei V
- Olhava, Edward J
- Caligiuri, Michael A
- Huang, Gang
- Bradner, James E
- Pollock, Roy M
- Armstrong, Scott A
Producer: 20151022
In:
Haematologica vol. 100
Availability: No items available.
|
|
|
7.
|
Reaction coupling between wild-type and disease-associated mutant EZH2. [electronic resource] by
- Swalm, Brooke M
- Knutson, Sarah K
- Warholic, Natalie M
- Jin, Lei
- Kuntz, Kevin W
- Keilhack, Heike
- Smith, Jesse J
- Pollock, Roy M
- Moyer, Mikel P
- Scott, Margaret Porter
- Copeland, Robert A
- Wigle, Tim J
Producer: 20150713
In:
ACS chemical biology vol. 9
Availability: No items available.
|
|
|
8.
|
Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l. [electronic resource] by
- Deshpande, Aniruddha J
- Chen, Liying
- Fazio, Maurizio
- Sinha, Amit U
- Bernt, Kathrin M
- Banka, Deepti
- Dias, Stuart
- Chang, Jenny
- Olhava, Edward J
- Daigle, Scott R
- Richon, Victoria M
- Pollock, Roy M
- Armstrong, Scott A
Producer: 20130603
In:
Blood vol. 121
Availability: No items available.
|
|
|
9.
|
MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. [electronic resource] by
- Bernt, Kathrin M
- Zhu, Nan
- Sinha, Amit U
- Vempati, Sridhar
- Faber, Joerg
- Krivtsov, Andrei V
- Feng, Zhaohui
- Punt, Natalie
- Daigle, Amanda
- Bullinger, Lars
- Pollock, Roy M
- Richon, Victoria M
- Kung, Andrew L
- Armstrong, Scott A
Producer: 20110907
In:
Cancer cell vol. 20
Availability: No items available.
|
|
|
10.
|
MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia. [electronic resource] by
- Riedel, Simone S
- Haladyna, Jessica N
- Bezzant, Matthew
- Stevens, Brett
- Pollyea, Daniel A
- Sinha, Amit U
- Armstrong, Scott A
- Wei, Qi
- Pollock, Roy M
- Daigle, Scott R
- Jordan, Craig T
- Ernst, Patricia
- Neff, Tobias
- Bernt, Kathrin M
Producer: 20160815
In:
The Journal of clinical investigation vol. 126
Availability: No items available.
|
|
|
11.
|
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2. [electronic resource] by
- Knutson, Sarah K
- Warholic, Natalie M
- Wigle, Tim J
- Klaus, Christine R
- Allain, Christina J
- Raimondi, Alejandra
- Porter Scott, Margaret
- Chesworth, Richard
- Moyer, Mikel P
- Copeland, Robert A
- Richon, Victoria M
- Pollock, Roy M
- Kuntz, Kevin W
- Keilhack, Heike
Producer: 20130719
In:
Proceedings of the National Academy of Sciences of the United States of America vol. 110
Availability: No items available.
|
|
|
12.
|
Mechanisms of Pinometostat (EPZ-5676) Treatment-Emergent Resistance in [electronic resource] by
- Campbell, Carly T
- Haladyna, Jessica N
- Drubin, David A
- Thomson, Ty M
- Maria, Michael J
- Yamauchi, Taylor
- Waters, Nigel J
- Olhava, Edward J
- Pollock, Roy M
- Smith, Jesse J
- Copeland, Robert A
- Blakemore, Stephen J
- Bernt, Kathrin M
- Daigle, Scott R
Producer: 20180626
In:
Molecular cancer therapeutics vol. 16
Availability: No items available.
|
|
|
13.
|
Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L. [electronic resource] by
- Basavapathruni, Aravind
- Jin, Lei
- Daigle, Scott R
- Majer, Christina R A
- Therkelsen, Carly A
- Wigle, Tim J
- Kuntz, Kevin W
- Chesworth, Richard
- Pollock, Roy M
- Scott, Margaret P
- Moyer, Mikel P
- Richon, Victoria M
- Copeland, Robert A
- Olhava, Edward J
Producer: 20130402
In:
Chemical biology & drug design vol. 80
Availability: No items available.
|
|
|
14.
|
Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma. [electronic resource] by
- Kawano, Satoshi
- Grassian, Alexandra R
- Tsuda, Masumi
- Knutson, Sarah K
- Warholic, Natalie M
- Kuznetsov, Galina
- Xu, Shanqin
- Xiao, Yonghong
- Pollock, Roy M
- Smith, Jesse S
- Kuntz, Kevin K
- Ribich, Scott
- Minoshima, Yukinori
- Matsui, Junji
- Copeland, Robert A
- Tanaka, Shinya
- Keilhack, Heike
Producer: 20170720
In:
PloS one vol. 11
Availability: No items available.
|
|
|
15.
|
Correction: Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma. [electronic resource] by
- Kawano, Satoshi
- Grassian, Alexandra R
- Tsuda, Masumi
- Knutson, Sarah K
- Warholic, Natalie M
- Kuznetsov, Galina
- Xu, Shanqin
- Xiao, Yonghong
- Pollock, Roy M
- Smith, Jesse J
- Kuntz, Kevin W
- Ribich, Scott
- Minoshima, Yukinori
- Matsui, Junji
- Copeland, Robert A
- Tanaka, Shinya
- Keilhack, Heike
Publication details: PloS one
In:
PloS one vol. 12
Availability: No items available.
|
|
|
16.
|
The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat. [electronic resource] by
- Kuntz, Kevin W
- Campbell, John E
- Keilhack, Heike
- Pollock, Roy M
- Knutson, Sarah K
- Porter-Scott, Margaret
- Richon, Victoria M
- Sneeringer, Chris J
- Wigle, Tim J
- Allain, Christina J
- Majer, Christina R
- Moyer, Mikel P
- Copeland, Robert A
- Chesworth, Richard
Producer: 20160726
In:
Journal of medicinal chemistry vol. 59
Availability: No items available.
|
|
|
17.
|
Quantitative analysis of histone deacetylase-1 selective histone modifications by differential mass spectrometry. [electronic resource] by
- Lee, Anita Y H
- Paweletz, Cloud P
- Pollock, Roy M
- Settlage, Robert E
- Cruz, Jonathan C
- Secrist, J Paul
- Miller, Thomas A
- Stanton, Matthew G
- Kral, Astrid M
- Ozerova, Nicole D S
- Meng, Fanyu
- Yates, Nathan A
- Richon, Victoria
- Hendrickson, Ronald C
Producer: 20090511
In:
Journal of proteome research vol. 7
Availability: No items available.
|
|
|
18.
|
Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas. [electronic resource] by
- Knutson, Sarah K
- Warholic, Natalie M
- Johnston, L Danielle
- Klaus, Christine R
- Wigle, Tim J
- Iwanowicz, Dorothy
- Littlefield, Bruce A
- Porter-Scott, Margaret
- Smith, Jesse J
- Moyer, Mikel P
- Copeland, Robert A
- Pollock, Roy M
- Kuntz, Kevin W
- Raimondi, Alejandra
- Keilhack, Heike
Producer: 20171011
In:
PloS one vol. 9
Availability: No items available.
|
|
|
19.
|
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. [electronic resource] by
- Daigle, Scott R
- Olhava, Edward J
- Therkelsen, Carly A
- Basavapathruni, Aravind
- Jin, Lei
- Boriack-Sjodin, P Ann
- Allain, Christina J
- Klaus, Christine R
- Raimondi, Alejandra
- Scott, Margaret Porter
- Waters, Nigel J
- Chesworth, Richard
- Moyer, Mikel P
- Copeland, Robert A
- Richon, Victoria M
- Pollock, Roy M
Producer: 20131023
In:
Blood vol. 122
Availability: No items available.
|
|
|
20.
|
Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. [electronic resource] by
- Duncan, Kenneth W
- Rioux, Nathalie
- Boriack-Sjodin, P Ann
- Munchhof, Michael J
- Reiter, Lawrence A
- Majer, Christina R
- Jin, Lei
- Johnston, L Danielle
- Chan-Penebre, Elayne
- Kuplast, Kristy G
- Porter Scott, Margaret
- Pollock, Roy M
- Waters, Nigel J
- Smith, Jesse J
- Moyer, Mikel P
- Copeland, Robert A
- Chesworth, Richard
Producer: 20160317
In:
ACS medicinal chemistry letters vol. 7
Availability: No items available.
|