Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures. [electronic resource]
Producer: 20190522Description: 1559-1570.e22 p. digitalISSN:- 1097-4172
- Amino Acid Transport Systems, Basic -- metabolism
- Animals
- Aspartate Carbamoyltransferase -- genetics
- Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) -- genetics
- Cell Line, Tumor
- Dihydroorotase -- genetics
- Female
- Genomics
- Humans
- Metabolomics
- Mice
- Mice, Inbred C57BL
- Mice, SCID
- Mitochondrial Membrane Transport Proteins
- Neoplasms -- metabolism
- Ornithine Carbamoyltransferase -- antagonists & inhibitors
- Phosphorylation -- drug effects
- Pyrimidines -- biosynthesis
- RNA Interference
- RNA, Small Interfering -- metabolism
- Sirolimus -- pharmacology
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Urea -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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