Azaspirane (N-N-diethyl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine) inhibits human multiple myeloma cell growth in the bone marrow milieu in vitro and in vivo. [electronic resource]
Producer: 20050712Description: 4470-6 p. digitalISSN:- 0006-4971
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Bone Marrow -- pathology
- Cell Communication
- Cell Proliferation -- drug effects
- Drug Synergism
- Endothelium, Vascular -- cytology
- Humans
- Interleukin-6 -- antagonists & inhibitors
- Mice
- Mice, SCID
- Multiple Myeloma -- drug therapy
- Neovascularization, Physiologic -- drug effects
- Signal Transduction -- drug effects
- Spiro Compounds -- pharmacology
- Stromal Cells -- drug effects
- Tumor Cells, Cultured
- Vascular Endothelial Growth Factor A -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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