Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation. [electronic resource]
Producer: 20140310Description: 71-82 p. digitalISSN:- 1532-1827
- Adenosine Triphosphate -- metabolism
- Amino Acid Sequence
- Animals
- Breast Neoplasms -- drug therapy
- Carbamates -- pharmacology
- Cell Growth Processes -- drug effects
- Cell Line, Tumor
- Cysteine -- metabolism
- Female
- HSP72 Heat-Shock Proteins -- metabolism
- HSP90 Heat-Shock Proteins -- antagonists & inhibitors
- HeLa Cells
- Humans
- MCF-7 Cells
- Mice
- Mice, Knockout
- Molecular Sequence Data
- Molecular Targeted Therapy
- Neoplasm Proteins -- metabolism
- Sulfhydryl Compounds -- pharmacology
- Sulfoxides -- pharmacology
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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