Unique overlap in the prerequisites for thrombin inhibition and oral bioavailability resulting in potent oral antithrombotics. [electronic resource]
Producer: 20021021Description: 4419-32 p. digitalISSN:- 0022-2623
- Administration, Oral
- Animals
- Aorta
- Biological Availability
- Biological Transport, Active
- Caco-2 Cells
- Crystallography, X-Ray
- Dogs
- Dose-Response Relationship, Drug
- Enzyme Inhibitors -- chemical synthesis
- Fibrinolytic Agents -- chemical synthesis
- Half-Life
- Humans
- In Vitro Techniques
- Models, Molecular
- Oligopeptides -- chemical synthesis
- Rats
- Structure-Activity Relationship
- Thrombin -- antagonists & inhibitors
- Thrombosis -- prevention & control
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Publication Type: Journal Article
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