miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding. [electronic resource]
Producer: 20190315Description: 1180-1188 p. digitalISSN:- 1476-5551
- Animals
- Cell-Derived Microparticles -- drug effects
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p21 -- metabolism
- Exosomes -- metabolism
- Humans
- Leukemia, Myeloid, Acute -- pathology
- Mice
- MicroRNAs -- metabolism
- Neoplastic Stem Cells -- pathology
- Tumor Suppressor Protein p53 -- metabolism
- rab GTP-Binding Proteins -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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