Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils. [electronic resource]
Producer: 20120406Description: 473-82 p. digitalISSN:- 1521-0103
- Animals
- Apoptosis -- drug effects
- Arachidonic Acids -- pharmacology
- Binding, Competitive
- CHO Cells
- Calcium Signaling -- drug effects
- Cell Membrane -- metabolism
- Cell Shape -- drug effects
- Chemokine CCL11 -- pharmacology
- Chemotaxis -- drug effects
- Complement C5a -- pharmacology
- Cricetinae
- Culture Media, Conditioned -- pharmacology
- Eosinophilia -- chemically induced
- Eosinophils -- cytology
- Guinea Pigs
- Humans
- Indoleacetic Acids -- pharmacokinetics
- Interleukin-13 -- metabolism
- Interleukin-5 -- pharmacology
- Leukotriene B4 -- pharmacology
- Lymphocyte Activation -- drug effects
- Mast Cells -- immunology
- Prostaglandin Antagonists -- pharmacokinetics
- Prostaglandin D2 -- analogs & derivatives
- Pulmonary Eosinophilia -- chemically induced
- Quinolines -- pharmacokinetics
- Radioligand Assay
- Rats
- Rats, Sprague-Dawley
- Receptors, Immunologic -- genetics
- Receptors, Prostaglandin -- genetics
- Recombinant Proteins -- metabolism
- Th2 Cells -- cytology
- Transfection
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Publication Type: Journal Article
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