Tumor-specific CTL kill murine renal cancer cells using both perforin and Fas ligand-mediated lysis in vitro, but cause tumor regression in vivo in the absence of perforin. [electronic resource]
Producer: 20020508Description: 3484-92 p. digitalISSN:- 0022-1767
- Animals
- Antineoplastic Agents -- toxicity
- Apoptosis -- genetics
- Apoptosis Regulatory Proteins
- Carcinoma, Renal Cell -- immunology
- Cell Line, Transformed
- Cytotoxicity, Immunologic -- genetics
- Epitopes, T-Lymphocyte -- administration & dosage
- Fas Ligand Protein
- Immunotherapy, Adoptive -- methods
- Intercellular Adhesion Molecule-1 -- metabolism
- Kidney Neoplasms -- immunology
- Ligands
- Lung Neoplasms -- immunology
- Lymphocyte Activation -- genetics
- Lymphocyte Function-Associated Antigen-1 -- metabolism
- Melanoma, Experimental -- immunology
- Membrane Glycoproteins -- biosynthesis
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Knockout
- Neoplasm Transplantation
- Perforin
- Pore Forming Cytotoxic Proteins
- T-Lymphocytes, Cytotoxic -- immunology
- TNF-Related Apoptosis-Inducing Ligand
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha -- toxicity
- fas Receptor -- metabolism
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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