Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development. [electronic resource]
Producer: 20200615Description: 708-718.e10 p. digitalISSN:- 2211-1247
- Cell Differentiation
- Chromatin -- metabolism
- Clustered Regularly Interspaced Short Palindromic Repeats -- genetics
- Endoderm -- cytology
- Hepatocyte Nuclear Factor 3-beta -- antagonists & inhibitors
- Human Embryonic Stem Cells -- cytology
- Humans
- Pluripotent Stem Cells -- cytology
- RNA Interference
- RNA, Guide, CRISPR-Cas Systems -- metabolism
- SOXF Transcription Factors -- genetics
- Signal Transduction
- Single-Cell Analysis
- Smad4 Protein -- genetics
- Transcription Factors -- antagonists & inhibitors
- Transforming Growth Factor beta -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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