Design and synthesis of novel biologically active thrombin receptor non-peptide mimetics based on the pharmacophoric cluster Phe/Arg/NH2 of the Ser42-Phe-Leu-Leu-Arg46 motif sequence: platelet aggregation and relaxant activities. [electronic resource]
Producer: 20040709Description: 3338-52 p. digitalISSN:- 0022-2623
- Amino Acid Motifs
- Animals
- Aorta -- drug effects
- Guanidines -- chemical synthesis
- Humans
- In Vitro Techniques
- Male
- Models, Molecular
- Molecular Mimicry
- Muscle Relaxation
- Muscle, Smooth, Vascular -- drug effects
- Oligopeptides -- chemical synthesis
- Platelet Aggregation Inhibitors -- chemical synthesis
- Rats
- Rats, Wistar
- Receptors, Thrombin -- agonists
- Structure-Activity Relationship
- Vasodilator Agents -- chemical synthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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