The angiotensin-converting enzyme 2/angiotensin (1-7)/Mas axis protects against lung fibroblast migration and lung fibrosis by inhibiting the NOX4-derived ROS-mediated RhoA/Rho kinase pathway. [electronic resource]
Producer: 20150910Description: 241-58 p. digitalISSN:- 1557-7716
- Angiotensin I -- physiology
- Angiotensin-Converting Enzyme 2
- Animals
- Cell Movement
- Cells, Cultured
- Collagen Type I -- metabolism
- Collagen Type I, alpha 1 Chain
- Fibroblasts -- physiology
- Male
- NADPH Oxidase 4
- NADPH Oxidases -- metabolism
- Peptide Fragments -- physiology
- Peptidyl-Dipeptidase A -- physiology
- Proto-Oncogene Mas
- Proto-Oncogene Proteins -- metabolism
- Pulmonary Fibrosis -- enzymology
- Rats, Wistar
- Reactive Oxygen Species -- metabolism
- Receptors, G-Protein-Coupled -- metabolism
- rho-Associated Kinases -- metabolism
- rhoA GTP-Binding Protein -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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