Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon. [electronic resource]
Producer: 20190109Description: 6187-6200 p. digitalISSN:- 1083-351X
- Adaptor Proteins, Signal Transducing
- Animals
- Azepines -- pharmacology
- Cell Cycle Proteins
- Cell Line, Tumor
- Conserved Sequence
- Cullin Proteins -- metabolism
- Humans
- Immunologic Factors -- metabolism
- Lenalidomide -- pharmacology
- Ligands
- Mice
- Molecular Probes
- Nuclear Proteins -- drug effects
- Peptide Hydrolases -- chemistry
- Proteasome Endopeptidase Complex -- metabolism
- Proteolysis
- T-Lymphocytes -- metabolism
- Thalidomide -- analogs & derivatives
- Transcription Factors -- drug effects
- Triazoles -- pharmacology
- Ubiquitin -- metabolism
- Ubiquitin-Protein Ligases -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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