Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death. [electronic resource]
Producer: 20200821Description: 832-842 p. digitalISSN:- 1538-7445
- Aniline Compounds -- pharmacology
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Aurora Kinase A -- antagonists & inhibitors
- Drug Synergism
- Gene Knockdown Techniques
- HEK293 Cells
- Humans
- Mice
- Mutagenesis, Site-Directed
- N-Myc Proto-Oncogene Protein -- metabolism
- Oncogene Proteins, Fusion -- genetics
- Paired Box Transcription Factors -- genetics
- Phosphorylation -- drug effects
- Primary Cell Culture
- Protein Stability -- drug effects
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- RNA, Small Interfering -- metabolism
- Rhabdomyosarcoma, Alveolar -- drug therapy
- Sulfonamides -- pharmacology
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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