Results
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1.
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Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). [electronic resource] by
- Miyashiro, Julie
- Woods, Keith W
- Park, Chang H
- Liu, Xuesong
- Shi, Yan
- Johnson, Eric F
- Bouska, Jennifer J
- Olson, Amanda M
- Luo, Yan
- Fry, Elizabeth H
- Giranda, Vincent L
- Penning, Thomas D
Producer: 20091207
In:
Bioorganic & medicinal chemistry letters vol. 19
Availability: No items available.
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2.
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PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow. [electronic resource] by
- Hopkins, Todd A
- Ainsworth, William B
- Ellis, Paul A
- Donawho, Cherrie K
- DiGiammarino, Enrico L
- Panchal, Sanjay C
- Abraham, Vivek C
- Algire, Mikkel A
- Shi, Yan
- Olson, Amanda M
- Johnson, Eric F
- Wilsbacher, Julie L
- Maag, David
Producer: 20200127
In:
Molecular cancer research : MCR vol. 17
Availability: No items available.
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3.
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Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors. [electronic resource] by
- Hopkins, Todd A
- Shi, Yan
- Rodriguez, Luis E
- Solomon, Larry R
- Donawho, Cherrie K
- DiGiammarino, Enrico L
- Panchal, Sanjay C
- Wilsbacher, Julie L
- Gao, Wenqing
- Olson, Amanda M
- Stolarik, DeAnne F
- Osterling, Donald J
- Johnson, Eric F
- Maag, David
Producer: 20160516
In:
Molecular cancer research : MCR vol. 13
Availability: No items available.
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4.
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Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase. [electronic resource] by
- Tong, Yunsong
- Torrent, Maricel
- Florjancic, Alan S
- Bromberg, Kenneth D
- Buchanan, Fritz G
- Ferguson, Debra C
- Johnson, Eric F
- Lasko, Loren M
- Maag, David
- Merta, Philip J
- Olson, Amanda M
- Osterling, Donald J
- Soni, Nirupama
- Shoemaker, Alexander R
- Penning, Thomas D
Producer: 20150115
In:
ACS medicinal chemistry letters vol. 6
Availability: No items available.
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5.
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Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer. [electronic resource] by
- Zhu, Gui-Dong
- Gong, Jianchun
- Gandhi, Viraj B
- Liu, Xuesong
- Shi, Yan
- Johnson, Eric F
- Donawho, Cherrie K
- Ellis, Paul A
- Bouska, Jennifer J
- Osterling, Donald J
- Olson, Amanda M
- Park, Chang
- Luo, Yan
- Shoemaker, Alexander
- Giranda, Vincent L
- Penning, Thomas D
Producer: 20121207
In:
Bioorganic & medicinal chemistry vol. 20
Availability: No items available.
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6.
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Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors. [electronic resource] by
- Dai, Yujia
- Hartandi, Kresna
- Soni, Niru B
- Pease, Lori J
- Reuter, David R
- Olson, Amanda M
- Osterling, Donald J
- Doktor, Stella Z
- Albert, Daniel H
- Bouska, Jennifer J
- Glaser, Keith B
- Marcotte, Patrick A
- Stewart, Kent D
- Davidsen, Steven K
- Michaelides, Michael R
Producer: 20080212
In:
Bioorganic & medicinal chemistry letters vol. 18
Availability: No items available.
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7.
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Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. [electronic resource] by
- Penning, Thomas D
- Zhu, Gui-Dong
- Gandhi, Viraj B
- Gong, Jianchun
- Liu, Xuesong
- Shi, Yan
- Klinghofer, Vered
- Johnson, Eric F
- Donawho, Cherrie K
- Frost, David J
- Bontcheva-Diaz, Velitchka
- Bouska, Jennifer J
- Osterling, Donald J
- Olson, Amanda M
- Marsh, Kennan C
- Luo, Yan
- Giranda, Vincent L
Producer: 20090223
In:
Journal of medicinal chemistry vol. 52
Availability: No items available.
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8.
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Synthesis and evaluation of a new generation of orally efficacious benzimidazole-based poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors as anticancer agents. [electronic resource] by
- Tong, Yunsong
- Bouska, Jennifer J
- Ellis, Paul A
- Johnson, Eric F
- Leverson, Joel
- Liu, Xuesong
- Marcotte, Patrick A
- Olson, Amanda M
- Osterling, Donald J
- Przytulinska, Magdalena
- Rodriguez, Luis E
- Shi, Yan
- Soni, Nirupama
- Stavropoulos, Jason
- Thomas, Sheela
- Donawho, Cherrie K
- Frost, David J
- Luo, Yan
- Giranda, Vincent L
- Penning, Thomas D
Producer: 20091215
In:
Journal of medicinal chemistry vol. 52
Availability: No items available.
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9.
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Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases. [electronic resource] by
- Curtin, Michael L
- Heyman, H Robin
- Frey, Robin R
- Marcotte, Patrick A
- Glaser, Keith B
- Jankowski, James R
- Magoc, Terrance J
- Albert, Daniel H
- Olson, Amanda M
- Reuter, David R
- Bouska, Jennifer J
- Montgomery, Debra A
- Palma, Joann P
- Donawho, Cherrie K
- Stewart, Kent D
- Tse, Chris
- Michaelides, Michael R
Producer: 20130104
In:
Bioorganic & medicinal chemistry letters vol. 22
Availability: No items available.
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10.
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Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors. [electronic resource] by
- Woods, Keith W
- Fischer, John P
- Claiborne, Akiyo
- Li, Tongmei
- Thomas, Sheela A
- Zhu, Gui-Dong
- Diebold, Robert B
- Liu, Xuesong
- Shi, Yan
- Klinghofer, Vered
- Han, Edward K
- Guan, Ran
- Magnone, Shayna R
- Johnson, Eric F
- Bouska, Jennifer J
- Olson, Amanda M
- de Jong, Ron
- Oltersdorf, Tilman
- Luo, Yan
- Rosenberg, Saul H
- Giranda, Vincent L
- Li, Qun
Producer: 20061124
In:
Bioorganic & medicinal chemistry vol. 14
Availability: No items available.
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11.
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Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families. [electronic resource] by
- Curtin, Michael L
- Frey, Robin R
- Heyman, H Robin
- Soni, Niru B
- Marcotte, Patrick A
- Pease, Lori J
- Glaser, Keith B
- Magoc, Terrance J
- Tapang, Paul
- Albert, Daniel H
- Osterling, Donald J
- Olson, Amanda M
- Bouska, Jennifer J
- Guan, Zhiwen
- Preusser, Lee C
- Polakowski, James S
- Stewart, Kent D
- Tse, Chris
- Davidsen, Steven K
- Michaelides, Michael R
Producer: 20121011
In:
Bioorganic & medicinal chemistry letters vol. 22
Availability: No items available.
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12.
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Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor. [electronic resource] by
- Penning, Thomas D
- Zhu, Gui-Dong
- Gong, Jianchun
- Thomas, Sheela
- Gandhi, Viraj B
- Liu, Xuesong
- Shi, Yan
- Klinghofer, Vered
- Johnson, Eric F
- Park, Chang H
- Fry, Elizabeth H
- Donawho, Cherrie K
- Frost, David J
- Buchanan, Fritz G
- Bukofzer, Gail T
- Rodriguez, Luis E
- Bontcheva-Diaz, Velitchka
- Bouska, Jennifer J
- Osterling, Donald J
- Olson, Amanda M
- Marsh, Kennan C
- Luo, Yan
- Giranda, Vincent L
Producer: 20100514
In:
Journal of medicinal chemistry vol. 53
Availability: No items available.
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13.
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Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. [electronic resource] by
- Penning, Thomas D
- Zhu, Gui-Dong
- Gandhi, Viraj B
- Gong, Jianchun
- Thomas, Sheela
- Lubisch, Wilfried
- Grandel, Roland
- Wernet, Wolfgang
- Park, Chang H
- Fry, Elizabeth H
- Liu, Xuesong
- Shi, Yan
- Klinghofer, Vered
- Johnson, Eric F
- Donawho, Cherrie K
- Frost, David J
- Bontcheva-Diaz, Velitchka
- Bouska, Jennifer J
- Olson, Amanda M
- Marsh, Kennan C
- Luo, Yan
- Rosenberg, Saul H
- Giranda, Vincent L
Producer: 20080911
In:
Bioorganic & medicinal chemistry vol. 16
Availability: No items available.
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14.
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Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. [electronic resource] by
- Glaser, Keith B
- Li, Junling
- Marcotte, Patrick A
- Magoc, Terrance J
- Guo, Jun
- Reuter, David R
- Tapang, Paul
- Wei, Ru-Qi
- Pease, Lori J
- Bui, Mai H
- Chen, Zehan
- Frey, Robin R
- Johnson, Eric F
- Osterling, Donald J
- Olson, Amanda M
- Bouska, Jennifer J
- Luo, Yanping
- Curtin, Michael L
- Donawho, Cherrie K
- Michaelides, Michael R
- Tse, Chris
- Davidsen, Steven K
- Albert, Daniel H
Producer: 20130124
In:
The Journal of pharmacology and experimental therapeutics vol. 343
Availability: No items available.
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15.
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Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor. [electronic resource] by
- Dai, Yujia
- Hartandi, Kresna
- Ji, Zhiqin
- Ahmed, Asma A
- Albert, Daniel H
- Bauch, Joy L
- Bouska, Jennifer J
- Bousquet, Peter F
- Cunha, George A
- Glaser, Keith B
- Harris, Christopher M
- Hickman, Dean
- Guo, Jun
- Li, Junling
- Marcotte, Patrick A
- Marsh, Kennan C
- Moskey, Maria D
- Martin, Ruth L
- Olson, Amanda M
- Osterling, Donald J
- Pease, Lori J
- Soni, Niru B
- Stewart, Kent D
- Stoll, Vincent S
- Tapang, Paul
- Reuter, David R
- Davidsen, Steven K
- Michaelides, Michael R
Producer: 20070514
In:
Journal of medicinal chemistry vol. 50
Availability: No items available.
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16.
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ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. [electronic resource] by
- Donawho, Cherrie K
- Luo, Yan
- Luo, Yanping
- Penning, Thomas D
- Bauch, Joy L
- Bouska, Jennifer J
- Bontcheva-Diaz, Velitchka D
- Cox, Bryan F
- DeWeese, Theodore L
- Dillehay, Larry E
- Ferguson, Debra C
- Ghoreishi-Haack, Nayereh S
- Grimm, David R
- Guan, Ran
- Han, Edward K
- Holley-Shanks, Rhonda R
- Hristov, Boris
- Idler, Kenneth B
- Jarvis, Ken
- Johnson, Eric F
- Kleinberg, Lawrence R
- Klinghofer, Vered
- Lasko, Loren M
- Liu, Xuesong
- Marsh, Kennan C
- McGonigal, Thomas P
- Meulbroek, Jonathan A
- Olson, Amanda M
- Palma, Joann P
- Rodriguez, Luis E
- Shi, Yan
- Stavropoulos, Jason A
- Tsurutani, Alan C
- Zhu, Gui-Dong
- Rosenberg, Saul H
- Giranda, Vincent L
- Frost, David J
Producer: 20070711
In:
Clinical cancer research : an official journal of the American Association for Cancer Research vol. 13
Availability: No items available.
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