Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-α-dependent necroptosis driven by RIP1 kinase and NF-κB. [electronic resource]
Producer: 20170911Description: 3399-409 p. digitalISSN:- 1476-5594
- Animals
- Antimetabolites, Antineoplastic -- pharmacology
- Apoptosis -- drug effects
- Caspases -- metabolism
- Cell Line, Tumor
- Colonic Neoplasms -- drug therapy
- Fluorouracil -- pharmacology
- HCT116 Cells
- HT29 Cells
- Humans
- Immunoblotting
- Immunohistochemistry
- Male
- Mice, Nude
- Microscopy, Electron
- NF-kappa B -- genetics
- Necrosis
- Oligopeptides -- pharmacology
- RNA Interference
- Receptor-Interacting Protein Serine-Threonine Kinases -- genetics
- Receptors, Tumor Necrosis Factor, Type I -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Tumor Burden -- drug effects
- Tumor Necrosis Factor-alpha -- metabolism
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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